NAD+ & NR Drops
Puretrex Liposomal NAD+ & NR Drops benefits panel: NAD+ support, cell-level energy, antioxidants and absorption
Puretrex Liposomal NAD+ & NR Drops bottle and box with 500mg NR and 250mg NAD+ to support cellular energy
Puretrex Liposomal NAD+ & NR Drops key benefits: NAD+ support, cellular energy, antioxidant polyphenols, absorption
Puretrex Liposomal NAD+ & NR Drops ingredients: 500mg NR, 250mg NAD+, 200mg resveratrol, 100mg CoQ10 per serving
Puretrex Liposomal NAD+ & NR Drops label check: every amount stated, sunflower lecithin, no proprietary blend, lab tested
Hand dropping Puretrex Liposomal NAD+ & NR Drops under the tongue once a day, 60 servings per bottle
Puretrex Liposomal NAD+ & NR Drops formula explained: 500mg nicotinamide riboside and 250mg NAD+ per daily serving

CELLULAR ENERGY SUPPORT

NAD+ & NR Drops

4.6 from 25 reviews

NR and NAD+ itself in a liposomal liquid under the tongue, for people who want cellular energy support without capsules.*

  • 60 servings
  • 1 dropper a day
  • 60-day supply
  • Cellular energy support for the long run.*
  • 500 mg NR plus 250 mg NAD+ directly, with resveratrol and CoQ10.
  • One dropper under the tongue. No capsules, no powder.
Quantity

Free US shipping over $50, or $5.99 standard. Ships in 1 business day, delivered in 2–5 business days by USPS.

Supplement Facts

1 ml (1 dropper) · 60 servings per bottle

Nicotinamide Riboside (NR)500mg
NAD+ (nicotinamide adenine dinucleotide)250mg
Trans-Resveratrol200mg
Coenzyme Q10100mg
Pterostilbene50mg
Liposomal Phosphatidylcholine200mg
BioPerine® Black Pepper5mg

Other ingredients: purified water, vegetable glycerin.

WHAT IT DOES

Three jobs, one dropper

NAD+ is the coenzyme every cell uses to make energy, and levels fall with age. This is the liquid way to top it up.

  • Cellular energy

    The kind you notice as steadier afternoons rather than a caffeine spike.*

  • Antioxidant support

    Trans-resveratrol, pterostilbene and CoQ10 help protect cells from oxidative stress.*

  • Morning ritual

    Hold it under the tongue for thirty seconds, swallow, then coffee. Done before the kettle boils.

WHAT'S INSIDE

Every ingredient. Why it's there.

Tap any ingredient to see why it is in the formula and at what dose. Doses per 1 dropper, as printed on the label.

Full dose table
Nicotinamide Riboside (NR) Nicotinamide Riboside (NR)500 mg
Why it's here

A form of vitamin B3 your cells turn into NAD+, the molecule they use to make energy. The main ingredient.*

NAD+ Directly NAD+ Directly250 mg
Why it's here

The energy molecule itself, alongside the raw material for it.*

Trans-Resveratrol Trans-Resveratrol200 mg
Why it's here

The antioxidant from red grape skins. It helps protect your cells from everyday wear.*

Coenzyme Q10 Coenzyme Q10100 mg
Why it's here

A compound every cell uses to make energy. Your body makes less of it with age.*

Pterostilbene Pterostilbene50 mg
Why it's here

Resveratrol's cousin, from blueberries. Same job: protecting cells from everyday wear.*

Liposomal Phosphatidylcholine Liposomal Phosphatidylcholine200 mg
Why it's here

A natural fat from sunflower. It wraps the actives so more of them get through the stomach.*

BioPerine® Black Pepper BioPerine® Black Pepper5 mg
Why it's here

Black pepper extract. It helps your body absorb the other ingredients, so less of each capsule is wasted.*

Vegan Non-GMO No hidden blends Liposomal

BEFORE YOU BUY ANY NAD+ DROPS

Check the label first

WHAT TO CHECKPURETREX
NR per serving500 mg
NAD+ per serving250 mg
Resveratrol formTrans
LiposomalYes
Proprietary blendNone

30-day money-back guarantee

Not for you? Email us within 30 days of delivery, opened or unopened, send it back and we refund you within 3–5 business days of receiving it. Return shipping is on you unless the item is faulty or incorrect.

  • 5 stars: 16 (64%)
  • 4 stars: 8 (32%)
  • 3 stars: 1 (4%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
K
Keni
Easy to use and dissolves quickly

This liquid supplement product arrived on time. I have been using this liquid in almost all my drinks. The taste is very reasonable. With the small bit of energy it gives me, I tend to take my dosage in the morning with breakfast. For me, that is the most effective time. I have had no negative side effects and feel this product is a good value for the money spent.

T
Tonya
Great energy boost! Easy to take!!

​I've been looking for a solid longevity supplement and decided to try these Puretrex Liposomal NAD+ & NR Drops after seeing the reviews.​The liquid format is incredibly convenient—much preferred over swallowing giant capsules. The dropper makes it easy to get an exact serving, and because it's liposomal delivery, it absorbs quickly. I’ve definitely noticed a nice, steady lift in my daily energy levels without any jitters. It doesn't really have a flavor which is great so theres not much of a after taste.​Will definitely keep this as a staple in my health routine!

Y
Ynnaile E.J.S
Liposomal NAD+ & NR Drops

This Putretrex Liposomal NAD+ & NR Drops are made with nicototinamide riboside (NR), NAD+ (Nicotinamide Adenine Dinucleotide), liposomal phospholipids, vegetable glycerin and black pepper extract combined with purified water. NAD has so many benefits related to improving cellular energy and DNA repair. Studies have also shown that long term use can reduce chronic inflammation and improve metabolism.I like that this is a dropper instead of another pill to take. The recommended dosage is 1 ml, which is one dropper full. The taste is very mild, it really doesn't taste like much, which makes it easier to swallow. I had some difficulty filling the dropper to the recommended dosage so I had to divide into two separate doses which is not ideal. This formulation is supposed to allow your body to absorb it easier. I've been taking this for about 3 weeks and it seems to help with me feeling more energetic and increased mental clarity. The price is a bit high but you get enough for a two month supply.

t
tonio d
I think it is worth it.

These supplements are sometimes difficult to review, especially if you are consuming multiple different kinds of things to improve your health and overall well being. This one is tricky because it relates to better aging, skin health, DNA repair and energy.Energy might be the easiest one to sense, if all things are the same, and you have an increase in energy, bam, there you go. I have noticed an increase in energy. I think it has helped.Skin, I cut out all sugar a few months ago, and my skin has had a huge improvement. I found out that I am “type 2”, so once I got that under control, my skin has been great. Maybe it is a combination of these together, either way I am happy with the results.This bottle is pricey. It could be a tough sell if you are on a tight budget. I am in a good place financially, so I see no harm in shelling out the money to potentially improve my overall health.Taste is not great, but it isn’t bad. It’ll be gone from your pallet in no time.I have not had any negative side effects that I can attribute to this supplement. Nothing at all.I say if you can swing it, go for it.

D
Dragife
NAD+ is a must have for anyone over 50!

First of all I LOVE the drop version of NAD+I have tried liqiid gel, gummies, capsules, you name it but this version is great! I just put 1/3 a dropper full under my tongue and it tastes great. Super easy to use.No side effects, no after taste, no smell. Mixes great in fluids also and is very soluble. Just stir or shake and its mixed in and ready to consume. You won't even notice it.Great value for the money. 2 month supply!!I have more energy and its like a fountain of youth in a bottle. NAD+ helps with cellular regeneration which affects every aspect of your life.I highly recommend this!

H
Hazelrah
Subtle energy

PURETREX Liposomal NAD+ & NR DropsThis is a nice and clean high quality formulation that contains a blend other complimentary compounds. They all seem to support cellular repair, cognative and metabolic function at a mitochondrial level, in some way. With the added liposomal absorption benefits, this a convienient and good tasting way to delivery these supplements. It has a rather soothing and subtle energizing effect on my system. I was pleasantly surprised. Kudos to the company for offering products like this. It’s made to be used directly under the tongue, or to drop into water. I tend to use it dropped into my mouth and then chase it with water. It tastes good, either way that it’s used. A little goes a long way, making it a good value for your money.

A
AJ
Another easy supplement delivery

For anyone who has taken supplements or researched it takes about three months of consistent used to notice observable positive change.No, I haven’t noticed any negative side effects. The taste is not overpowering, which will make this extremely easy to be consistent and taking.I don’t know that this is necessarily connected to this, but I have noticed that my skin has become more clear in my acne.It does similar pricey, but again if it keeps us healthy, we’re going to save in other areas.I have noticed my energy improve a little bit. I have been overall taking more supplements to try to support my well-being so can I fully attribute it to this not necessarily but it’s not making things worse.Like I said with anything you have to give it a good three months of consistent used to be able to see. So if you are interested, I would recommend just trying one thing at a time. See what you notice and possibly add something else to it.So far, I have nothing negative to add and I’m gonna continue using this to see how it impacts my health.The one thing that does seem a little confusing is the instruction on how much it take. It says serving size 1 mL which is one dropper and then on the direction for use. It says take .33 mL Dailey under the tongue mixed with food or drink. So that part is the part that is uncertain. So I’m going with the lower dose to be safe.

M
Mike Roberts
Strong Cellular And Aging Support

Nicotinamide Riboside in essence is Vitamin B3 and is converted into NAD by the body. Nad is used by the body for Cellular and Heart support as well as assisting the body with the aging process including anti inflammation and metabolic support. This supplement also contains Tran Resveratrol and Coenzyme Q10, both strong antioxidants. The droplets if taken straight have a neutral taste to them. The dropper is well marked for proper dosage and easy to use. The box and bottle were both sealed when received and the quality is good. Expiration date on the bottle is 09/02/2028. Good Value and Highly Recommended.

U
Unapologetically Me…
Impressive Formula and Feels More Like an Advanced Wellness Blend Than Pure NAD+ Support!

This supplement honestly has one of the more impressive-looking ingredient profiles I’ve seen for an NAD-focused liquid formula. It combines NR, NAD+, resveratrol, pterostilbene, CoQ10, phosphatidylcholine, and BioPerine all together, which gives it a much more comprehensive “cellular energy/longevity” approach compared to basic NAD products. I also like that it uses a liposomal delivery system and includes phosphatidylcholine rather than simply throwing the word “liposomal” on the label without support ingredients.The liquid format is convenient, easy to take, and probably preferable for people who dislike large capsules. The ingredient amounts are also noticeably stronger than many cheaper NAD blends, especially with the 500 mg of NR and added CoQ10. For the price, the overall value actually seems fairly solid considering how many separate supplements this combines into one product.Overall, this blend seems to be a higher-end and more thoughtfully formulated NAD/NR liquid supplement than many generic alternatives. Good ingredients, decent transparency, convenient dosing, effective formulation and solid value!

A
Amazon Customer
Clean NAD+/NR Formula, Good Value, No Side Effects, Minor Dropper Issue

This is a strong NAD+/NR liquid supplement with a formulation that makes sense to me. The liposomal delivery, NAD+ and NR combination, and clean ingredient approach all check the boxes I look for in this type of product.The flavor is just okay. It is not pleasant, but it is mild and easy to tolerate, which I prefer over something artificially flavored.At about $0.50 per day, the value is very good for a 60-day supply, especially given the third-party testing and overall formulation quality.I did not notice any negative side effects while using this. Energy and focus felt steady and clean, without any stimulant-like effects or crashes. No improvements to skin tone or texture.The only real downside for me is the dropper. A full dose is 1 mL, but I could not get the dropper to pull even 0.75 mL consistently, so each dose took two pulls. Not a big issue, just an unnecessary annoyance.Overall, this is a well-formulated, good-value supplement with a tolerable taste, no noticeable side effects, and one minor usability flaw.

E
EmmaV
Chasing Energy Without Caffeine… Let’s See

Energy hasn’t been the same lately—more like running on half a battery most days. Coffee helps, but the crashes aren’t worth it anymore. That’s what led to trying this NAD+ liquid. The idea of supporting energy at a cellular level sounded promising, especially without stimulants.First impression—super easy to use. The dropper makes dosing simple, and taking it under the tongue or mixing it into a drink doesn’t take much effort. Taste is… not great, but not terrible either. Slightly medicinal, something you just get used to.A week in, nothing dramatic yet. Maybe a slight improvement in focus during the day, but it’s subtle. From what’s expected, this kind of supplement takes time, so there’s no rushing results here.What stands out is the “clean energy” feel—no jitters, no sudden spikes or crashes, which is a nice change from caffeine. That said, it’s still early, and the effects aren’t strong enough yet to say it’s a game changer.Downsides? Definitely the price—it’s on the higher side. Also, the results so far feel mild, so it requires patience and consistency to really judge it.For now, it feels like a slow build. Not instant, not dramatic, but possibly something that works quietly over time to tell about effectiveness.

A
Amazon Customer
Give energy boost. Very expensive if not on sale.

A dose is just a little drop and you can sort of adjust the drop size, but it's hard to measure the actual dosage from that.It's easy to use if you've ever used a dropper to dose medicine. The taste is fine, and it's a little drop so if you don't like the taste you can have some water after that.I have no way of knowing if the ingredients listed are in the potency claimed. And they benefits are not approved by the FDA. After a couple of days of using, I did notice a little increase in energy, but it was also sunny after several days of rain and cloudiness so I'm not sure if this is the drops or a placebo / vitamin D / sunshine effect.I did not notice any improvement in skin, hair, or any other possible benefits. I'm not sold on the long-term effects of these serums, but if it wasn't so expensive, I'd suggest others try and read more reviews to see what others are claiming of the benefits over long term use.Puretrex seems to have a good reputation on Amazon, so their products and ingredients recipe are likely to be as good or better than similar items.Unfortunately, this is very expensive (over twice as expensive as several competitors and a common theme with Puretrex products) so the entry point is quite high if you wanted to try something like this for a month to see if the components and compounds made any difference.If this is on significant discount and you want to try mullein leaf extract, lungwort, or other ingredients, this is worth a buy. Otherwise, it's just way too expensive.

K
KH
Clean, high quality form of NAD

NAD+ supplements are everywhere right now, and I’d say most of them probably aren’t worth the hype. BUT after a few weeks with Puretrex’s Liposomal NAD+ and NR Drops I am genuinely impressed. The formula combines Nicotinamide Riboside, NAD+, Trans-Resveratrol, Pterostilbene, CoQ10, and Liposomal Phosphatidylcholine, enhanced with BioPerine for optimal absorption. That is a legitimately stacked lineup, and each ingredient earns its place. The liposomal liquid format is where this really separates itself from cheaper capsule alternatives, designed to protect the compounds through digestion and deliver them more efficiently. It is also alcohol-free, sugar-free, non-GMO, vegan, and lab tested with no unnecessary fillers, which I always appreciate. Results for me have been subtle but real. Better mental clarity and steadier energy throughout the day, no stimulant feeling. Definitely worth a try!

D
Dutchess the reviewer
Interesting.. I think it's working

Day three with this and I’m starting to understand the vibe. It’s not one of those “hit you in the face” energy products—it’s more lowkey, steady. I’ve been feeling a little more focused and consistent through the day, not bouncing all over the place. I actually like that it’s not giving jittery energy or a crash later.Still early, so I’m not buying into all the “cellular energy” and longevity talk just yet, but it’s moving in the right direction. Easy to take, doesn’t upset my stomach, and fits into my routine without effort. If it keeps building like this, I’ll have more to say—but for now, solid and promising.

F
Fr Bro & Mrs M
Supports Stamina, Focus & Overall Performance

As a strength training/biohacking enthusiast, I take this 7-in-1 longevity and cell support supplement daily because it helps maintain cellular energy production, mitochondrial efficiency and daily vitality and longevity--especially as NAD+ naturally declines with age. As I lift weights, this product helps support my stamina, focus and overall performance.Highly recommended.TLDR:Ingredients include Liposomal NAD+, NR, Trans-Resveratrol, Pterostilbene, CoQ10, Liposomal PC and BioPerine®.Featuring Liposomal NAD+, Trans-Resveratrol and NR, this premium blend supports healthy DNA repair, cellular resilience and optimal mitochondrial performance to help one feel and function younger longer. With Pterostilbene, CoQ10 and Liposomal PC, it helps support cognitive function, memory and brain health.They claim that its advanced liposomal technology maximizes absorption of NAD+ peptides and cofactors for faster, more effective results--delivering powerful anti-aging and energy benefits at the cellular level.

A
Ally Cat
High-Quality Formula with Noticeable Energy Support

The Puretrex Liposomal NAD+ & NR Drops Supplement presents as a high-quality and thoughtfully formulated product. It features a blend of seven complementary compounds designed to work together, and the overall formulation reflects strong attention to quality. It’s labeled vegan, non-GMO, alcohol-free, sugar-free, gluten-free, and HALAL certified, and it’s manufactured in the UK. Most importantly, it’s third-party lab tested, which adds a reassuring level of confidence in its purity and potency.The bottle is clear and informative, displaying both manufacturing and expiration dates along with a two-year shelf life. I received mine just a couple of months after production, so it felt very fresh with plenty of time to use the full bottle.Because it’s a liquid, it’s very easy to take and simple to incorporate into a daily routine. The flavor is mild and not unpleasant, with no lingering aftertaste. I also didn’t experience any stomach discomfort while using it.In my personal experience, I noticed improved energy, healthier-looking skin, and an overall sense of well-being. As always, individual results may vary, but it’s been a positive addition for me.Considering the ingredient quality, third-party testing, freshness, and overall performance, the price feels very reasonable. Based on my experience, I’m comfortable giving this supplement a 5-star rating.

S
Sal P.
Noticed a steady energy boost, but the taste takes some getting used to

I’ve been taking these Liposomal NAD+ & NR Drops for a few weeks now, and I’m definitely feeling a difference in my daily energy levels. Unlike caffeine, which gives me jitters and a crash, this feels like a more natural, sustained "wakefulness" throughout the afternoon.Pros:Effectiveness: I feel less sluggish during my workouts and more focused at work.Absorption: The liposomal liquid format seems to hit my system much faster than the capsules I’ve used in the past.Convenience: The dropper makes it very easy to adjust the dosage.Cons:Flavor: The taste is quite strong and a bit medicinal. I’ve found that mixing it into a small amount of juice or a smoothie makes it much more palatable than taking it straight.Price: It is a bit on the pricier side for a 2-ounce bottle, though the quality of the ingredients seems to justify it.Overall, it is a solid supplement for anyone looking to support cellular health and longevity. If you can get past the initial taste, the benefits for mental clarity and energy are worth it.

DIRECTIONS

Simple enough to stick

NAD+ & NR Drops routine
  • 1 1 dropper under the tongue

    Hold it there for 30 seconds, then swallow.

  • 2 Morning, before coffee

    NAD+ supports energy, so it belongs at the start of the day.

  • 3 Give it a month

    Most people notice steadier afternoons after a few weeks, not a few days.

SUITABILITY

Made for your routine

Who NAD+ & NR Drops is for

Great fit if you

  • Are past 40 and want to do something for cellular energy
  • Prefer drops to capsules
  • Take it as a long-term daily routine

Not for you if you

  • Are pregnant, breastfeeding or under 18.
  • Take prescription medication. Check with your doctor first.

QUESTIONS

Before you order

Drops or the capsules?

The capsules add NMNH and more cofactors. The drops carry a higher NR dose plus NAD+ itself in a liquid. Pick on format.

Why under the tongue?

Sublingual absorption bypasses the stomach. Hold the drops for 30 seconds before swallowing.

Does it need refrigerating?

Store it in a cool, dry place away from sunlight, as the label says.

PAIRS WELL WITH

Complete the routine

  • NAD+ NR & NMNH Complex
    NAD+ NR & NMNH Complex $49.50 60-day supply
    Why add it

    The capsule formula with two precursors and twelve actives, two a day.*